I love (neon) because it’s an organic light that lives and breathes.

His project, dubbed “Habana Light Neon + Signs”, has so far restored around 50 signs, reflecting a broader revival in Havana.“I love (neon) because it’s an organic light that lives and breathes.“Obscure zones would go from being marginal to being photographed,” said Lopez Nieves, who then started restoring other neon signs, using historic documents such as old photographs for guidance. There are only a few craftsmen left in Cuba who know how to bend the neon tubes into letters and fill them with gas to create different colours. It would host a museum and workshops, as well as a store for new and classic designs.”.Lopez Nieves, whose work plays with memory and nostalgia, set about restoring the neon lights of a dozen cinemas as a project for the Havana Biennial arts festival in 2015. The Communist-run island - labouring under a U.Amid a global neon revival, the initiative started attracting enthusiasts from all over the world, who offered their expertise, he said.HAVANA: After dusk in Havana, an ice-blue neon sign illuminates the faded facade of the Cine El Megano, one of many abandoned movie houses in the Cuban capital, lighting up a once vibrant corner at the heart of the Caribbean city that had gone pitch black in recent decades.Lopez Nieves hopes to safeguard that knowledge with his Custom Hanging light box Signs Manufacturers next project: the creation of a neon centre in the abandoned art deco cinema “Cine Rex”. “A personal project turned into a social project.Over the decades, tropical weather wrought havoc on their neon signs. embargo - often lacked the funds and know-how to fix them. It is the work of Cuban artist Kadir Lopez Nieves, who is restoring the vintage signs of the cinemas, hotels and cabarets that lit up Havana’s nightlife in its 1950s heyday..He plans to open it in December. The city, one of the architectural jewels of Latin America, has been enjoying a tourism boom. His work delighted locals.“They called it the Broadway or Paris of the Caribbean because it had so much light and brilliance,” said Lopez Nieves, during an interview in his workshop and gallery.As elsewhere, other forms of lighting - such as LEDs - proved cheaper and the ornate neon signs were abandoned.”The initiative has become self-financing, thanks to the sale of new commercial signs to Cuba’s fledgling private sector, costing between $200 and $3,000.Shining incandescent from afar, the sign also helped to make the run-down area more salubrious by chasing away shady characters, he said.Close to Havana’s seafront, the “Bar Cabana” sign flashes red, while around the corner “La Farmacia” restaurant sign burns white.“It’s lending more life to the city at night,” said Alberto Echavarria, 68, guarding a carpark down the road from the Cine Megano.Foreign expertise has come in handy, Lopez Nieves said.The glowing neon italic letters fill the building’s colonial facade with an art-deco accent between the doors below and the wraparound balcony above.”After Fidel Castro’s 1959 leftist revolution, many of Havana’s ritzy entertainment venues, often run by American mobsters and frequented by the rich and famous, were shuttered or slowly became run-down.Havana was switched off in terms of light. “But when I started out the project..S. “Neon is having an important revival,” he said, “and I‘m glad we’re part of that. He said the sign recalled the once “fabulous” ambiance of the neighbourhood, which lies close to Havana’s neo-classical Capitol Building.Lopez Nieves says he has a large contract to restore the lights at Havana’s famed Tropicana nightclub, which in its prime boasted famous patrons such as Hollywood stars Frank Sinatra and Humphrey Bogart. And then to discover an entire city: it’s almost like finding a treasure box,” said Jeff Friedman, who runs a New York-based neon sign manufacturer, during a trip to Havana

The study has been published in Proceedings of the National Academy of Sciences.

The study has been published in Proceedings of the National Academy of Sciences. She found that people reacted to this structure in the same way, irrespective of whether they were presented with speech or signs."This is a significant finding for the deaf community because sign language is Punching letter Signs their legacy.Next, Berent asked what happens when people see doubling in signs (signs with two identical syllables). The modality (speech or sign) is secondary."It's not about the stimulus, it's really about the mind, and specifically about the language system," said Berent. Human brains can grasp the structure of language regardless of whether it is presented in speech or in sign.When a word is presented by itself (or as a name for just one object), people avoid doubling. The subjects were English speakers who had no knowledge of a sign language. Berent's lab shows that our brain detects some deep similarities between speech and sign language. "Part of our mandate, through the support of the NSF, is to reveal the complex structure of sign language, and in so doing, disabuse the public of this notion.According to Northeastern University, language is not simply about hearing sounds or moving our mouths."Sign language has a structure, and even if you examine it at the phonological level, where you would expect it to be completely different from spoken language, you can still find similarities. For example, they rate slaflaf (with doubling) worse than slafmak (with no doubling). When our brain is "doing language," it projects abstract structure. The present study focused on English and Hebrew. It defines their identity, and we should all recognize its value.Berent says these findings show that our brains are built to deal with very different types of linguistic inputs."There is a misconception in the general public that sign language is not really a language," said researcher Iris Berent. This allows for English speakers, for example, extending their knowledge of language to sign language."To come to this conclusion, Berent's lab studied words (and signs) that shared the same general structure.In the study, Berent studied words and signs with doubling, ones that show full or partial repetition.. It's also significant to our human identity, generally, because language is what defines us as a species," he added. We can apply some of the rules of our spoken language phonology to signs," said Berent. "These results suggest that our knowledge of language is abstract and amodal. What's even more remarkable is that our brain can extract some of this structure even when we have no knowledge of sign language. Washington D.C. But when doubling signaled a systematic change in meaning, participants now preferred it. They disliked doubling for singular objects, but they systematically preferred it if (and only if) doubling signaled plurality. To Berent's surprise, these subjects responded to signs in the same way they responded to the words. The results from this paper confirm what some scientists have long thought, but hasn't truly been grasped by the general public--language is language no matter what format it takes. Hebrew speakers showed this preference when doubling signaled a diminutive, in line with the structure of their language.When our brain is "doing language," it projects abstract structure.: In contrary to popular belief that language is not limited to speech, a recent study reveals that people also apply the rules of their spoken language to sign language.To help further support these findings, Berent and her lab intend to examine how these rules apply to other languages."Currently there is a debate as to what role sign language has played in language evolution, and whether the structure of sign language shares similarities with spoken language. She found that responses to these forms shift, depending on their linguistic context

And you call this a table, this battered old school desk?

Bhutto was at Oxford with you may have given her that easy familiarity that breeds contempt. Sorry, I digress’. A Satire News exclusive. KT: ‘I say, old chap, have a care will you? You’re on a slippery slope. However, there were two notable exceptions. T. Can we hunker down to the questions?’ KT: ‘I like that, “hunker down”. And you call this a table, this battered old school desk? A pox on you’. KT: ‘I think I’ve conceded enough brownie points for one evening I’ll have you on my programme next and give you a taste of your own medicine’. Instead he agreed to meet us at our unpretentious office, over a cup of matka chai and dhoklas. A pox on you??’ KT: ‘Just an old English expression, when you want to curse or put the mockers on someone. Pip pip, toodle-oo, mud in your eye, and all that rot’. We downloaded it for free from Kindle. And speaking of salt, en passant, have you read my book ‘More Salt than Pepper’? Available on Flipkart, Snapdeal and Amazon. Tell us, of all the famous people you have interviewed on television, who were the most difficult?’ KT: ‘All of them. He speaks in clipped, Oxford accented English. Jayalalithaa’. What does it feel like, to be on the other side of the table, in a manner of speaking?’Karan Thapar (KT): ‘Mr. Impeccably dressed, suit and tie or bow tie perfectly synchronised to match his well groomed and distinguished silver grey hair. Went out of currency in the 18th century, but I am partial to a smidgen of Ye Olde English. So good of you to agree to be interviewed by us at our modest premises. J. Given our shoestring budget, we could not afford to invite the celebrated anchor to a posh 5 star location. Fire away’. That’s why my programme graphic features a sword cutting a swathe across the screen. My audience research tells me that most of my subjects squirmed a goodish bit under my close questioning. The cut and thrust of debate is never better exemplified than to cross swords with a pugnacious foe. T, if calling you that is not a liberty. KT: ‘No, they’re scrumptious, though I would have preferred fish fingers with mayonnaise. Yes, of course. As in, ‘Interesting you should say that Mani Shankar Aiyar, because at an election rally in your constituency in Mayiladuthurai (makes a complete hash of the pronunciation), you said just the opposite, and I quote…….SN: ‘Most interesting, but can you name some subjects who challenged even your formidable array of attacking arsenal?’KT: ‘Hmmm, nice one. KT: ‘You’re too kind. More to the point, we know not why. You described your premises as modest.SN: ‘It’ll be an honour, Mr. The late Benazir Bhutto and the equally late Dr.SN: ‘Both women’. Right, on with the questions. Calling me by my first name? It’s too soon.Karan Thapar is one of India’s most respected journalists. KT: ‘Idiot box, eh? Thank you for the compliment, though it sounded distinctly backhanded. His subjects find his burrowing and darting eyes a bit disconcerting, as if they were caught with their hands in the cookie jar. Don’t be fooled. Another couple of questions, and I must make tracks’.SN: ‘To get back to the two iron ladies, both of them really had you squirming, didn’t they? Your piercing looks and scathing irony did not impress them one bit’. Custom Galvanized stainless steel letter Signs Suppliers I see them as innocent sacrificial lambs. With our compliments’. But I do welcome your dripping sarcasm, which is what we love on the idiot box’. Makes for spicy television. You should have seen me at Oxford during the debates’.’ Given Karan Thapar’s notoriously elusive personality, Satire News’ dogged persistence finally paid off. ‘Array of attacking arsenal’. And please take this doggie bag of dhoklas with you. Won’t happen again, cross my heart and hope to die. We await his reappearance, in another avatar, with bated breath. T, but they certainly had your measure.Thapar to you, if it doesn’t put you out. Offence is my best form of defence, even if that meant being offensive. Let’s get back to your question, lest I be accused of dissembling. We proffer, with bowed head, our unconditional apology. Sometimes, I act submissive, but it is deceptive. And another thing. To say nothing of his unnerving habit of making pointed references to something the subject had said, and totally forgotten, several years ago.SN: ‘Extremely sorry, Mr. You are right, of course. Your acute powers of observation are astounding, my fine, feathered friend.Thapar. These diversions are pleasant but my time is precious. A technical knock-out’. You have a way with words. We hardly know each other. That’s one royalty fee up the spout. You have a natural bent for alliteration, my friend. KT: ‘How very perspicacious of you.’ KT: ‘Damn Kindle and its free downloads. Prepares the viewer for the thrust and parry’. This imagined conversation took place a few weeks prior to his departure. But Dr. From this point on, you’re on a timer. SN: ‘I daresay Mr.SN: ‘Er, thank you, I guess. There’s a special offer on. Jayalalithaa was something else. Suggest you order it eftsoons..SN: ‘Actually, we have already read the book Mr. The great man agreed to be interviewed in camera, which actually means without cameras, in the convoluted ways of the English language. By the way, I hope the dhoklas are not too salty’. She had you on the mat and you didn’t last the count. That is a very good description, if a tad understated. He is sharp, thorough in his preparation and To The Point, to accord his erstwhile television chat show its designated brand name. I select my subjects for their high degree of difficulty. Top that for alliteration!’SN: ‘Pugnacious, perspicacious? I’ll need a thesaurus. T.The author is a brand consultant who loves music, cricket and good humour.Satire News (SN): ‘Good morning, Karan. Sartorial elegance personified. Of course, the fact that Ms.’SN: ‘Righty ho, Mr. Could do with a lick of paint’.Karan Thapar’s ‘To the Point’ has been conspicuously off the air. No? Super

The researchers are now investigating whether the ECO system is effective against other visual disorders

The researchers are now investigating whether the ECO system is effective against other visual disorders, including Stargardt disease, which is a form of inherited juvenile macular degeneration, primarily affecting the central portion of the visual field.The exterior of the nanoparticle is coated with nucleic acids that act as targeting agents, drawing the delivery system to the retina and facilitating uptake by RPE cells.Those with LAC2 carry a mutated RPE65 gene and suffer from profound vision loss from birth.Washington D. They are also studying whether the nanoparticles can be used with the CRISPR/Cas9 gene-editing technique to treat genetic lesions related to retinal degenerative diseases. The mutated gene fails to produce RPE65 protein in the retinal pigment epithelium (RPE), a cell layer critical for protecting photoreceptors (rods and cones). Testing showed a significant increase in light-induced electrical activity from the eyes to the brain, indicating the rods and cones were operating as they should in the visual cycle."The promise of this technology is it localizes the drug to the photoreceptor cells, sparing the liver and kidney from exposure," said researcher Krzysztof Palczewski..The condition is one of the most common causes of blindness in children, according to the National Institutes of Health, affecting two to three of every 100,000 newborns.Lu and colleagues designed a lipid-based nanoparticle called ECO to deliver healthy RPE65 genes to RPE cells.Leader Zheng-Rong Lu said that they believe this technology can deliver almost any type of gene to tackle inherited visual disorders.Researchers at Case Western Reserve University have developed gene-carrying nanoparticles that home in on target cells and prevent vision loss in mice with a human form of Leber congenital amaurosis.C.The therapeutic effect lasted 120 days in treated mice.Though this research focused on the form of the disease called Leber congenital amaurosis 2, or LCA2, the scientists and engineers involved in the study believe the technology holds promise for other forms of LCA as well as other inherited diseases that lead to severe vision loss or blindness.The study appears in the journal Molecular Therapy Nucleic Acids. No improvements were observed in untreated mice. To track activity, Lus team included a fluorescent markerFollowing injection into the retina of mice, the researchers could see fluorescent green concentrating in RPE cells. The protein is an essential constituent of the visual cycle that converts light to electrical signals to the brain.: A new gene-delivery system for an inherited form of blindness shows promise, according to a recent study. The ECO can  Wholesale Custom Color letter Signs be tailored to fit the cargo.While other researchers focus on using modified viruses to deliver genes for therapy, sometimes the genes are too large for viruses to carry, Lu said